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冷激蛋白的研究进展
引用本文:郭建军,龚兴国.冷激蛋白的研究进展[J].生物化学与生物物理进展,2002,29(5):691-695.
作者姓名:郭建军  龚兴国
作者单位:浙江大学生物技术系,杭州,310027
基金项目:浙江省自然科学基金资助项目(396007)及浙江大学曹光彪科技基金项目(171026).
摘    要:冷激蛋白(CSPs)广泛存在于革兰氏阳性菌和阴性菌中,它是细胞在应对冷刺激时所产生的一系列7 ku左右的蛋白质,结构上富含芳香族氨基酸,起着重要的分子伴侣作用,能够增强细胞抵御冷激环境胁迫的能力.以大肠杆菌、枯草杆菌、嗜热链球菌、沙门氏杆菌等为例,介绍各种冷激蛋白在产生、结构、调控等方面的异同,以及它在生产、生活中的应用价值.

关 键 词:冷激蛋白,分子伴侣,细胞生长
收稿时间:2002/3/14 0:00:00
修稿时间:5/8/2002 12:00:00 AM

Progress in Cold Shock Protein
GUO Jian-Jun and GONG Xing-Guo.Progress in Cold Shock Protein[J].Progress In Biochemistry and Biophysics,2002,29(5):691-695.
Authors:GUO Jian-Jun and GONG Xing-Guo
Affiliation:Department of Biotechnology, Zhejiang University, Hangzhou 310027,China;Department of Biotechnology, Zhejiang University, Hangzhou 310027,China
Abstract:A set of 7 ku proteins (named cold shock proteins) is strongly induced in response to a rapid decrease in growth temperature when bacteria adapt to temperatures below their growth temperature. They are rich in aromatic and basic amino acids, suggested to function as molecular chaperones and make cell enhance ability to survive freezing after a cold shock treatment. The similarity and difference of cold shock proteins were described in structure, regulation of expression and function etc. In addtion, the value of them for human kind is in mention.
Keywords:cold shock protein  molecular chaperone  cell growth
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