Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2. |
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| Authors: | M Equestre D Genovese F Cavalieri L Fiore R Santoro and R Perez Bercoff |
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| Affiliation: | Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy. |
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| Abstract: | Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type 2 712 and Sabin vaccine strains. This pattern of mutation appeared to be a feature common to all neurovirulent variants of poliovirus type 2. |
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