CD4-independent, productive infection of a neuronal cell line by human immunodeficiency virus type 1. |
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| Authors: | X L Li T Moudgil H V Vinters and D D Ho |
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| Affiliation: | Department of Medicine, Cedars-Sinai Medical Center and UCLA School of Medicine 90048. |
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| Abstract: | One neuronal cell line (SK-N-MC) was found to be susceptible to productive infection by multiple isolates of the human immunodeficiency virus type 1 (HIV-1). Characterization of SK-N-MC cells showed that these cells are neuroectodermal in origin in that they express dopamine hydroxylase, catecholamines, neuron-specific enolase, and neurofilaments. Despite their susceptibility to HIV-1 infection, SK-N-MC cells had no detectable CD4 and this infection was not blocked by anti-CD4 monoclonal antibodies (OKT4A, Leu3A) or recombinant soluble CD4. These experiments demonstrated that certain cells of neuroectodermal origin are susceptible to infection in vitro by HIV-1 via a CD4-independent mechanism. |
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