High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. |
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Authors: | C Rinaldo X L Huang Z F Fan M Ding L Beltz A Logar D Panicali G Mazzara J Liebmann M Cottrill |
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Affiliation: | C Rinaldo, X L Huang, Z F Fan, M Ding, L Beltz, A Logar, D Panicali, G Mazzara, J Liebmann, M Cottrill, et al. |
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Abstract: | Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with levels present in intermediate and advanced progressors. CD8+ memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors. |
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