HLA and mate selection: no evidence in South Amerindians. |
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| Authors: | P W Hedrick and F L Black |
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| Affiliation: | Department of Biology, Arizona State University, Tempe 85287-1501, USA. hedrick@hedricklab.la.asu.edu |
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| Abstract: | There have been reports of nonrandom mating (negative-assortative mating) or preference for individuals of different major histocompatibility complex (MHC) genotypes in both mice and humans. We have examined the association of HLA-A and HLA-B genotypes, both for each locus by itself and for two-locus genotypes, in mates of 194 couples from 11 South Amerindian tribes. The proportion of couples sampled averaged >50% of the total matings with progeny for 10 of the tribes. In nearly all cases, HLA-sharing proportions were very close to those expected from random mating, suggesting strong negative-assortative mating for MHC is not present in these South Amerindians. |
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