| 草地退化影响高原鼠兔血清总IgG水平、肠道寄生物感染及肝脏和肾脏指数 |
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| 引用本文： | 吴学琴,陈慧青,张璐,尚国珍,吴雁,边疆晖.草地退化影响高原鼠兔血清总IgG水平、肠道寄生物感染及肝脏和肾脏指数[J].兽类学报,2022,42(5):531-539. |
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| 作者姓名： | 吴学琴 陈慧青 张璐 尚国珍 吴雁 边疆晖 |
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| 作者单位： | 1.中国科学院西北高原生物研究所，中国科学院高原生物适应与进化重点实验室，西宁 8100012.中国科学院大学，北京 1000493.青海省动物生态基因组学重点实验室，西宁 8100014.杭州师范大学生命科学学院，杭州 310012 |
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| 基金项目： | 国家自然科学基金(31870397);青海省自然科学基金青年项目(2021-ZJ-945Q);中国科学院A类先导专项(XDA2005010406);中国科学院 青海省人民政府三江源国家公园联合研究专项(LHZX-2020-01) |
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| 摘 要： | 高原鼠兔 (Ochotona curzoniae) 作为青藏高原高寒草地生态系统中的关键物种，其种群数量随着过度放牧导致的草地退化而暴发式增长。阐明此过程中高原鼠兔天然免疫能力及肝脏和肾脏器官指数的变化，对深入揭示青藏高原草地退化引起的高原鼠兔种群暴发机理具有重要意义。本研究在青海海北高寒草地生态系统国家野外科学观测研究站地区，调查了轻度、中度、重度退化草地中高原鼠兔洞口数量，并测定了成体高原鼠兔血清总IgG含量、肠道寄生物感染状况及肝脏和肾脏指数。结果发现：随着草地退化，高原鼠兔洞口数量和血清总IgG水平显著增加；绦虫和线虫的感染率和感染强度以及肝脏和肾脏指数均显著降低。雄性对绦虫的感染率和肝脏指数显著低于雌性；雌性在重度退化草地中对绦虫和线虫的感染率及感染强度显著低于轻度退化草地。以上结果表明，过度放牧介导的草地退化增强了高原鼠兔的天然免疫功能，缓解了毒素对肝脏和肾脏的损伤，进而可能促进其种群暴发式增长。
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| 关 键 词： | 高原鼠兔 草地退化 食物蛋白 天然免疫 肠道寄生物 种群暴发 |
| 收稿时间： | 2022-07-12 |
Grassland degradation affects serum total IgG level,intestinal parasitic infection and liver and kidney indices of plateau pika |
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| Xueqin WU,Huiqing CHEN,Lu ZHANG,Guozhen SHANG,Yan WU,Jianghui BIAN.Grassland degradation affects serum total IgG level,intestinal parasitic infection and liver and kidney indices of plateau pika[J].Acta Theriologica Sinica,2022,42(5):531-539. |
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| Authors: | Xueqin WU Huiqing CHEN Lu ZHANG Guozhen SHANG Yan WU Jianghui BIAN |
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| Affiliation: | 1.Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China2.University of Chinese Academy of Science, Beijing 100049, China3.Qinghai Key Laboratory of Animal Ecological Genomics, Xining 810001, China4.School of Life and Environment Sciences, Hangzhou Normal University, Hangzhou 310012, China |
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| Abstract: | As a key species in the alpine grassland ecosystem of the Qinghai?Tibet Plateau, the plateau pika (Ochotona curzoniae) population increased rapidly with grassland degradation. Understanding the changes in innate immune function and organ index of liver and kidney indices of plateau pika is of great significance for further revealing the physiological mechanism of plateau pika population outbreak caused by grassland degradation on the Qinghai?Tibet Plateau. In this study, we investigated the number of burrow entrances, measured serum total IgG levels, intestinal parasitic infection, and liver and kidney indices of adult plateau pikas inhabiting lightly, moderately, and heavily degraded grassland (LD, MD and HD) at Qinghai Haibei National Field Research Station of Alpine Grassland Ecosystem. Our results showed that with grassland degradation, the number of burrow entrances and serum total IgG levels increased significantly, while the prevalence and intensity of infection of cestodes and nematodes as well as liver and kidney indices decreased markedly. The prevalence of infection of cestodes and liver index in males were significantly lower than those in females, and the prevalence and intensity of infection of cestodes and nematodes in females in HD were significantly lower than those in LD. These results indicate that grassland degradation induced by overgrazing enhances the innate immune of plateau pika and alleviate the damage of toxins to liver and kidney, which may promote population outbreaks. |
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| Keywords: | Plateau pika (Ochotona curzoniae) Grassland degradation Food protein Innate immune Intestinal parasites Population outbreaks |
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