An independent validation study of loci associated with nematode resistance in sheep |
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| Authors: | O M Keane J P Hanrahan K M McRae B Good |
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| Affiliation: | 1. Animal & Bioscience Department, Teagasc, Grange, Dunsany, Co. Meath, Ireland;2. School of Veterinary Medicine, University College Dublin, Dublin 4, Ireland;3. Animal & Bioscience Department, Teagasc, Athenry, Co. Galway, Ireland |
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| Abstract: | Gastrointestinal nematode infection is a constraint on sheep production worldwide. Selective breeding programmes to enhance resistance to nematode infection are currently being implemented in a number of countries. Identification of loci associated with resistance to infection or causative mutations for resistance would enable more effective selection. Loci associated with indicator traits for nematode resistance has been identified in previous studies. In this study, Scottish Blackface, Texel and Suffolk lambs were used to validate the effects at eight genomic regions previously associated with nematode resistance (OAR3, 4, 5, 7, 12, 13, 14, 21). No SNP was significantly associated with nematode resistance at the region‐wide level but seven SNPs in three of the regions (OAR4, 12, 14) were nominally associated with trichostrongyle egg count in this study and six of these were also significant when fitted as single SNP effects. Nematodirus egg count was nominally associated with SNPs on OAR3, 4, 7 and 12. |
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| Keywords: | association nematode infection selective breeding
Ovis aries
SNP
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