| 注射Bestatin对幼年大鼠分辨学习的影响 |
| |
| 引用本文： | 邹伟,张世仪.注射Bestatin对幼年大鼠分辨学习的影响[J].动物学研究,1998,19(4):277-281. |
| |
| 作者姓名： | 邹伟 张世仪 |
| |
| 作者单位： | [1]辽宁师范大学生物系 [2]中国医学科学院基础医学研究所 |
| |
| 摘 要： | 以Ｓｐｒａｑｕｅ－Ｄａｗｌｅｙ大鼠为实验动物，从出生后第１天起，每日皮下分别注射氨基肽酶的抑制剂Ｂｅｓｔａｔｉｎ（１ｍｇ／ｋｇ（ｂ．ｗ））以及钠络酮（２ｍｇ／ｋｇ（ｂ．ｗ）＋Ｂｅｓｔａｉｎｇ（１ｍｇ／ｋｇ（ｂ．ｗ）），对照组注射等量的生理盐水，连续注射１４天，观察：１６日龄幼鼠的吸乳迷津分辨学习（ＡＤＬ），３０日龄Ｙ迷津明暗分辨学习（ＡＤＬ），３０日龄Ｙ迷津明暗分辨学习（ＢＤＬ）行为，４５日龄幼鼠
|
| 关 键 词： | Bestatin 幼鼠 纳洛酮 分辨学习 |
EFFECT OF BESTATIN ON THE DISCRIMINATION LEARNING IN INFANT RATS |
| |
| ZOU Wei.EFFECT OF BESTATIN ON THE DISCRIMINATION LEARNING IN INFANT RATS[J].Zoological Research,1998,19(4):277-281. |
| |
| Authors: | ZOU Wei |
| |
| Abstract: | Infant Spraque-Dawley rat pups were divided into three groups and received daily injection of saline,bestatin an aminopeptidase inhibitor,1 mg/kg(b.w) or naloxone 2 mg/kg(b.w) +bestatin 1 mg/kg(b.w) respectively from postnatal days 1-14. They were trained in the appetitive discrimination learning (ADL) at the age of 16 days,then in the bright discrimination learning of Y-maze (BDL) at 30 days of age. On postnatal days 45,the content of brain protein and zinc in cerebral cortex,hippocampus,cerebellum,pons,and diencephalon of the rats were examined. The results showed that the dose of bestatin inhibited significantly the learning behavior in ADL and BDL,and lowered the content of protein and zinc in hippocampus of the infant rats. Whereas,naloxone reversed partly the effect of bestatin. This suggested that the endogenous opiotide whould regulate some learning behavior through influncing synthesis of protein in hippocampus during postnatal brain development of infant rats. |
| |
| Keywords: | Bestatin Infant rats Naloxon Discrimination |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《动物学研究》浏览原始摘要信息 |
|
点击此处可从《动物学研究》下载全文 |
|
