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Molecular Characterization of a Variant of Bacillus anthracis-Specific Phage AP50 with Improved Bacteriolytic Activity |
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| Authors: | Shanmuga Sozhamannan Michael McKinstry Shannon M Lentz Matti Jalasvuori Farrell McAfee Angela Smith Jason Dabbs Hans-W Ackermann Jaana K H Bamford Alfred Mateczun and Timothy D Read |
| Abstract: | The genome sequence of a Bacillus anthracis-specific clear plaque mutant phage, AP50c, contains 31 open reading frames spanning 14,398 bp, has two mutations compared to wild-type AP50t, and has a colinear genome architecture highly similar to that of gram-positive Tectiviridae phages. Spontaneous AP50c-resistant B. anthracis mutants exhibit a mucoid colony phenotype. |
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