Analysis of PB2 protein from H9N2 and H5N1 avian flu
virus |
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| Authors: | Danishuddin Asad Ullah Khan |
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| Affiliation: | 1.Bioinformatics distributed Information sub-centre, AMU, Aligarh-202002, India;2.Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh-202002, India |
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| Abstract: | Influenza A viruses of subtype H9N2 are wide spread among poultry
and other mammalian species. Crossing the species barrier
from poultry to human occurred in recent years creating a
pandemic of H9N2 virus. It is known that the pathogenicity
of H9N2 is lower than H5N1. Nonetheless, it is important to
establish the molecular functions of H9N2 viral proteins. We
studied mutations in the polymerase protein PB2 of H9N2 from
different strains and compared it with the highly pathogenic
H5N1. The mutation M294T was found to be important in the
N-myristoylation domain of Ck/UP/2573/India/04(H9N2)
isolate. Prediction of secondary structures and PROSITE
motif assignments were performed for PB2 to gain functional
insight. Subsequently, the effect of mutations in secondary
structures among strains is discussed. |
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| Keywords: | PB2 protein H5N1 H9N2 mutations N-myristoylation domain |
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