| KISS-1/GPR54基因及其在生殖中的作用 |
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| 引用本文： | 冯涛,储明星,张英杰.KISS-1/GPR54基因及其在生殖中的作用[J].遗传,2008,30(4):419-425. |
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| 作者姓名： | 冯涛 储明星 张英杰 |
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| 作者单位： | 1. 甘肃农业大学动物科学技术学院,兰州,730070
2. 中国农业科学院北京畜牧兽医研究所,中国农业科学院家养动物遗传资源与种质创新重点开放实验室,北京,100094 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，国家高技术研究发展计划(863计划)，国家自然科学基金 |
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| 摘 要： | KISS-1及其受体GPR54基因对青春期的正常启动具有重要作用。青春期开始前后, 动物下丘脑中KISS-1和GPR54 mRNA水平很高, Kisspeptins(KISS-1基因产物)通过激活GPR54增加促性腺激素的释放, KISS-1基因的表达受性腺类固醇激素的调控。GPR54基因突变可以导致人和鼠的特发性促性腺激素分泌不足性腺机能减退症和促性腺激素依赖性性早熟。文章还介绍了KISS-1、GPR54基因的结构、表达、多态性以及和其它生殖调控因子之间的相互关系。
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| 关 键 词： | KISS-1基因 GPR54基因 Kisspeptin 生殖 调控 |
| 收稿时间： | 2007-10-07 |
| 修稿时间： | 2007年10月7日 |
KISS-1/GPR54 genes and their role in reproduction |
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| FENG Tao,CHU Ming-Xing,ZHANG Ying-Jie.KISS-1/GPR54 genes and their role in reproduction[J].Hereditas,2008,30(4):419-425. |
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| Authors: | FENG Tao CHU Ming-Xing ZHANG Ying-Jie |
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| Affiliation: | College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China. fengt@gsau.edu.cn |
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| Abstract: | KISS-1 gene and its receptor gene GPR54 play key roles in the initiation of puberty onset. The peptide product of the KiSS-1 gene, Kisspeptins stimulate gonadotrophins release to initiate puberty through the expression of GPR54 gene in the brain. So the level of KISS-1 and GPR54 mRNA in hypothalamus was very high on the onset of puberty. The expression of KISS-1gene was regulated by steroid hormone in different nuclei within the forebrain to control the reproduction in puberty. Loss of function mutations of GPR54 gene could cause idiopathic hypogonadotropic hypogonadism (IHH) and gonadotrophin-dependant premature puberty. This review also introduced the structure, expression, homology comparison, polymorphism of KISS-1 and GPR54 genes and their interrelation with other regulators of reproduction. |
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| Keywords: | Kisspeptin |
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