M.Smal is an N4-methylcytosine specific DNA-methylase. |
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| Authors: | S Klimasauskas D Steponaviciene Z Maneliene M Petrusyte V Butkus and A Janulaitis |
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| Affiliation: | Institute of Applied Enzymology, Vilnius, Lithuania, USSR. |
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| Abstract: | An enzymatic activity rendering DNA immune to the action of the Smal restriction endonuclease in the presence of S-adenosyl-L-methionine has been detected in Serratia marcescens Sb. This methylase, M.Smal, modifies the second cytosine residue of the substrate sequence CCCGGG yielding N4-methylcytosine. |
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