TUSC3: a novel tumour suppressor gene and its functional implications |
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| Authors: | Xinshuang Yu Chunjuan Zhai Yujun Fan Jiandong Zhang Ning Liang Fengjun Liu Lili Cao Jia Wang Juan Du |
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| Affiliation: | 1. Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China;2. Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong University, Shandong University, Jinan, China;3. Medical Management Service Center of Shandong Provincial Health and Family Planning Commission, Jinan, China;4. Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China;5. China Institute of Veterinary Drugs Control, Beijing, China |
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| Abstract: | The tumour suppressor candidate 3 (TUSC3) gene is located on chromosome region 8p22 and encodes the 34 kD TUSC3 protein, which is a subunit of the oligosaccharyl transferase responsible for the N‐glycosylation of nascent proteins. Known to be related to autosomal recessive mental retardation for several years, TUSC3 has only recently been identified as a potential tumour suppressor gene. Based on the structure and function of TUSC3, specific mechanisms in various diseases have been investigated. Several studies have demonstrated that TUSC3 is an Mg2+‐transporter involved in magnesium transport and homeostasis, which is important for learning and memory, embryonic development and testis maturation. Moreover, dysfunction or deletion of TUSC3 exerts its oncological effects as a modulator by inhibiting glycosylation efficiency and consequently inducing endoplasmic reticulum stress and malignant cell transformation. In this study, we summarize the advances in the studies of TUSC3 and comment on the potential roles of TUSC3 in diagnosis and treatment of TUSC3‐related diseases, especially cancer. |
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| Keywords: | tumour suppressor candidate 3 oligosaccharyl transferase tumourgenesis N‐glycosylation reaction |
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