| p53基因多态性和脑外伤预后及临床意义 |
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| 引用本文： | 顾奕,于明琨,吕立权,孙克华,卢亦成,侯立军.p53基因多态性和脑外伤预后及临床意义[J].现代生物医学进展,2011,11(14):2685-2690. |
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| 作者姓名： | 顾奕 于明琨 吕立权 孙克华 卢亦成 侯立军 |
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| 作者单位： | 上海第二军医大学附属长征医院神经外科,上海,200003 |
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| 摘 要： | 目的:研究颅脑外伤患者中P53等位基因与基因型的频率分布,探讨其与脑损伤预后的关联性,为脑损伤患者预后提供部分参数依据.方法:选择各型颅脑损伤患者141例,正常对照者144人,患者按GCS格拉斯哥评分法进行分类;采用PCR基因型检测法检测P53等位基因,基因计数法计算等位基因频率;统计学分析等位基因和基因型在脑外伤组与正常对照组、预后良好组与预后不良组的频率分布的差异,并综合分析患者年龄、性别、GCS以及P53各等位基因等因素对脑外伤患者预后的影响.结果:在颅脑外伤患者和正常对照者中P53等位基因和基因型的频率分布,差异均无统计学意义(P＞0.05);等位基因Arg相对于Pro的OR为1.140,基因型Arg/Pro、Arg/Arg相对于Pro/Pro的OR分别为0.890和1.170.在重型脑外伤患者(3≤GCS≤8分)86例中,预后良好31例,预后不良55例,基因型对预后不良的影响:非Pro/Pro相对于Pro/Pro的OR为0417,非Arg/Pro相对于Arg/Pro的OR为0.419,非Arg/Arg相对于Arg/Arg的OR为3.667.在所有脑外伤患者中,预后良好组和预后不良组的患者年龄、性别差异均无统计学意义(P＞0.05);GCS、P53等位基因差异具有显著统计学意义(P＜0.01).结论:在重型颅脑患者中,基因型Arg/Arg有增加预后不良的风险;脑外伤预后与患者的年龄、性别无关联,与GCS、P53基因密切相关.
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| 关 键 词： | 脑外伤预后 p53 等位基因 基因型 |
Research on the Relevance between P53 Gene Polymorphism and Brain Injury Prognosis and its Mechanism |
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| GU Yi,YU Ming-kun,LV Li-quan,SUN Ke-hua,LU Yi-cheng,HOU Li-jun.Research on the Relevance between P53 Gene Polymorphism and Brain Injury Prognosis and its Mechanism[J].Progress in Modern Biomedicine,2011,11(14):2685-2690. |
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| Authors: | GU Yi YU Ming-kun LV Li-quan SUN Ke-hua LU Yi-cheng HOU Li-jun |
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| Affiliation: | GU Yi1,YU Ming-kun2,LV Li-quan3,SUN Ke-hua2,LU Yi-cheng3,HOU Li-jun1(Shanghai Second Military Medical University attached Long March hospital neurosurgery department postcode 200003) |
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| Abstract: | Objective: Research in P53 allele and genotype frequency distribution in patients with craniocerebral trauma;discussed its relationship with brain damage prognosis;to provide some parameters according for the prognosis of patients with brain damage.Methods: Selected patients with craniocerebral injury 141 cases,normal controls were 144 people;classified according to the GCS Glasgow grading method;inspected P53 alleles by PCR genotype assay;calculated the allele frequency by gene counting method;by Statistic... |
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| Keywords: | Brain trauma prognosis p53 Alleles Genotypes |
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