| 广泛性焦虑障碍血清25-羟维生素D、维生素B12与认知功能和临床疗效的关系 |
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| 引用本文： | 闵 妍,吴 迪,陈怡环,吕润欣,徐淑莉.广泛性焦虑障碍血清25-羟维生素D、维生素B12与认知功能和临床疗效的关系[J].现代生物医学进展,2023(22):4276-4279. |
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| 作者姓名： | 闵 妍 吴 迪 陈怡环 吕润欣 徐淑莉 |
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| 作者单位： | 空军军医大学第一附属医院心理科 陕西 西安 710032 |
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| 基金项目： | 陕西省重点研发计划一般项目（2023-YBSF-185) |
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| 摘 要： | 摘要 目的：探讨广泛性焦虑障碍（GAD）患者血清25-羟维生素D25（OH）D]、维生素B12（VB12）与认知功能和临床疗效的关系。方法：选择2018年4月~2022年6月期间空军军医大学第一附属医院心理科门诊收治的186例GAD患者作为GAD组。另选取同期于我院体检健康的志愿者120例作为对照组。采用威斯康星卡片分类测验（WCST）评估并对比两组患者的认知功能，检测并对比两组患者的血清25（OH）D、VB12水平。采用Pearson相关性分析血清25（OH）D、VB12与认知功能的相关性。GAD组给予常规治疗，按照治疗效果分为有效组和无效组，对比有效组和无效组在治疗前后血清25（OH）D、VB12水平变化。结果：GAD组的血清25（OH）D、VB12水平低于对照组（P<0.05）。对照组完成总分类数、正确反应数、总反应数均多于GAD组，错误应答数、持续性错误数少于GAD组（P<0.05）。Pearson相关性分析结果显示，血清25（OH）D、VB12水平与错误应答数、持续性错误呈负相关；而与总分类数、正确反应数、总反应数呈正相关（P<0.05）。186例患者中，痊愈36例，疗效显著53例，有效62例，无效35例。按照治疗情况将患者分为有效组（n=151）和无效组（n=35）。两组治疗后血清25（OH）D、VB12水平均升高，且有效组高于对照组（P<0.05）。结论：GAD患者的25（OH）D、VB12水平下降，且与其认知功能下降有关，25（OH）D、VB12水平较低的GAD患者其治疗效果也相对更差，提示临床诊疗过程中应密切关注患者25（OH）D、VB12水平以制定相应的治疗措施。
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| 关 键 词： | 广泛性焦虑障碍 25-羟维生素D 维生素B12 认知功能 临床疗效 |
| 收稿时间： | 2023/5/5 0:00:00 |
| 修稿时间： | 2023/5/28 0:00:00 |
Relationship between Serum 25-Hydroxyvitamin D, Vitamin B12 and Cognitive Function and Clinical Efficacy in Patients with Generalized Anxiety Disorder |
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| Abstract: | ABSTRACT Objective: To explore the relationship between serum 25-hydroxyvitamin D 25(OH)D], Vitamin B12 (VB12) and cognitive function and clinical efficacy in patients with generalized anxiety disorder (GAD). Methods: 186 patients with GAD who were admitted to the Department of Psychology Clinic of the First Affiliated Hospital of Air Force Military Medical University from April 2018 to June 2022 were selected as GAD group.Another 120 healthy volunteers who were underwent physical examinations in our hospital during the same period were selected as control group. The cognitive function in patients was evaluated and compared between two groups by the Wisconsin Card Sorting Test (WCST), and the serum 25(OH)D and VB12 levels in patients were detected and compared between two groups. The correlation between serum 25(OH)D, VB12 and cognitive function was analyzed by the pearson correlation. GAD group received routine treatment, they were divided into effective group and ineffective group based on the efficacy, and the changes in serum 25(OH)D and VB12 levels were compared before and after treatment between effective group and ineffective group. Results: The serum 25(OH)D and VB12 levels in GAD group were lower than those in control group (P<0.05). The total number of completed categories, number of correct reactions, and total number of reactions in the control group were higher than those in the GAD group, while the number of incorrect responses and the number of persistent errors were lower than those in the GAD group (P<0.05). Pearson correlation analysis showed that serum levels of 25 (OH) D and VB12 were positively correlated with tThe total number of completed categories, number of correct reactions, and total number of reactions; There was a negative correlation with the number of incorrect responses and the number of persistent errors (P<0.05). Among 186 patients, 36 cases were cured, 53 cases were significantly effective, and 62 cases were effective, and 35 cases were ineffective. Patients were divided into effective group (n=151) and ineffective group (n=35) according to the treatment situation. The serum 25(OH)D and VB12 levels increased in two groups after treatment, and effective group were higher than those in control group (P<0.05). Conclusion: The 25(OH)D and VB12 levels in patients with GAD decrease, and which is related to the decline in cognitive function, patients with GAD with lower 25(OH)D and VB12 levels also have poorer treatment outcomes, which is suggested that close attention should be paid to the 25(OH)D and VB12 levels in patients during clinical diagnosis and treatment to develop corresponding treatment measures. |
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| Keywords: | Generalized anxiety disorder 25-hydroxyvitamin D Vitamin B12 Cognitive function Clinical efficacy |
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