Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia |
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| Authors: | Voulgaropoulou F Tan B Soares M Hahn B Ratner L |
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| Affiliation: | Departments of Medicine, Washington University, St. Louis, Missouri 63110, USA. |
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| Abstract: | We analyzed bone marrow and blood from human immunodeficiency virus type 1 (HIV-1)-infected individuals and described the HIV-1 quasispecies in these cellular compartments. HIV-1 isolates from the bone marrow of thrombocytopenic patients contained distinct amino acids in the V3 loop and infected T-cell lines, implicating this virus in the development of thrombocytopenia. |
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