A novel self‐assembling peptide with UV‐responsive properties |
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| Authors: | Ran Wei Cheng‐Cheng Jin Jing Quan Hua‐li Nie Li‐Min Zhu |
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| Affiliation: | 1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, Peoples Republic of China;2. National Engineering Research Center for Dyeing and Finishing of Textiles, Donghua University, Shanghai, Peoples Republic of China |
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| Abstract: | A novel heptapeptide comprising Ile‐Gln‐Ser‐Pro‐His‐Phe‐Phe (IQSPHFF) identified and found to undergo self‐assembly into microparticles in solution. To understand the effects of ultraviolet (UV) irradiation on the self‐assembly process, IQSPHFF solutions were exposed to the UV light of 365 nm at room temperature. This exposure was found to have a profound effect on the morphology of the self‐assembled aggregates, converting the microparticles to nanorod shapes. Circular dichroism and FTIR studies indicated distinct structural differences in the arrangements of the peptide moieties before and after UV irradiation. However, Mass spectrum analysis and high performance liquid chromatography of the peptide molecules before and after UV irradiation demonstrated that the chemical structure of IQSPHFF was not changed. UV–visible spectroscopy and fluorescence spectroscopy studies showed that the absorption peak both increased after UV irradiation. Overall, our data show that the heptapeptide with UV‐responsive properties. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 272–278, 2014. |
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| Keywords: | self‐assembly heptapeptide UV nanostructure |
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