Studies on the antioxidant activity of some thiazolidinedione,imidazolidinedione and rhodanine derivatives having a flavone core |
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| Authors: | Pawe? Berczyński Aleksandra K?adna Teresa Piechowska Irena Kruk Oya Bozda?‐Dündar Hassan Y Aboul‐Enein Meltem Ceylan‐Unlusoy Rahmiye Ertan |
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| Affiliation: | 1. West Pomeranian University of Technology, Szczecin Institute of Physics, Szczecin, Poland;2. Department of History of Medicine and Medical Ethics, Pomeranian Medical University, Szczecin, Poland;3. Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey;4. Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo, Egypt |
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| Abstract: | A series of flavonyl‐2,4‐thiazolidinedione, imidazolidinedione and rhodanine derivatives were tested for their antioxidant activity as scavengers of oxygen free radicals. Free radical scavenging activities, including superoxide anion radical  , hydroxyl radical (HO?) and 2,2′‐diphenyl‐1‐picrylhydrazyl free radical have been evaluated using chemiluminescence, electron paramagnetic resonance and spin trapping with 5,5‐dimethyl‐1‐pyrroline‐1‐oxide as a spin trap. Potassium superoxide in dimethylsulfoxide and 18‐crown‐6 ether were used for the production of  . Hydroxyl radical was generated using the Fenton reaction. Ten of the eleven examined compounds exhibited decrease in chemiluminescence, but there were large differences in the decrease, ranging from 16% to 89%; also, two of these compounds increased light emission by about 200%. On the contrary, all compounds tested exhibited 30–68% scavenging HO? and 25–96% scavenging the DPPH? radical respectively. Possible mechanisms are proposed to explain the results. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | flavone derivatives radical scavenging activity chemiluminescence EPR study |
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