Modulation of caveolae by insulin/IGF‐1 signaling regulates aging of Caenorhabditis elegans |
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| Authors: | Hana Boocholez Lorna Moll Filipa Carvalhal Marques Ludmila Golodetzki Yuval Nevo Tayir Elami Ehud Cohen |
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| Affiliation: | 1. Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel – Canada, The Hebrew University School of Medicine, Jerusalem, Israel;2. Computation Center, Hebrew University‐Hadassah Medical School, Jerusalem, Israel |
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| Abstract: | Reducing insulin/IGF‐1 signaling (IIS) extends lifespan, promotes protein homeostasis (proteostasis), and elevates stress resistance of worms, flies, and mammals. How these functions are orchestrated across the organism is only partially understood. Here, we report that in the nematode Caenorhabditis elegans, the IIS positively regulates the expression of caveolin‐1 (cav‐1), a gene which is primarily expressed in neurons of the adult worm and underlies the formation of caveolae, a subtype of lipid microdomains that serve as platforms for signaling complexes. Accordingly, IIS reduction lowers cav‐1 expression and lessens the quantity of neuronal caveolae. Reduced cav‐1 expression extends lifespan and mitigates toxic protein aggregation by modulating the expression of aging‐regulating and signaling‐promoting genes. Our findings define caveolae as aging‐governing signaling centers and underscore the potential for cav‐1 as a novel therapeutic target for the promotion of healthy aging. |
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| Keywords: | aging caveolae insulin/IGF‐1 signaling lifespan proteostasis |
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