Measles virus infection of B lymphocytes permits cellular activation but blocks progression through the cell cycle. |
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| Authors: | M B McChesney J H Kehrl A Valsamakis A S Fauci M B Oldstone |
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| Affiliation: | Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037. |
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| Abstract: | Measles virus infection of unstimulated B lymphocytes suppresses both proliferation and differentiation into immunoglobulin-secreting cells. However, mitogenic stimulation of these infected cells results in cell volume enlargement, rapid RNA synthesis, and the expression of cell surface activation antigens 4F2, HLA-DS, and transferrin receptor. The cellular genes c-myc and histone 2B are induced during early G1 and S phase of the cell cycle, respectively, and viral RNA synthesis can be detected during this interval. However, total RNA synthesis is decreased at 48 h after stimulation, and the histone 2B RNA steady-state level at 48 h is fivefold less than that in uninfected cells. This sequence of events defines an arrest in the G1 phase of the cell cycle in measles virus-infected B cells. |
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