Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells. |
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| Authors: | E Schuuring L van Deemter H Roelink and R Nusse |
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| Affiliation: | Division of Molecular Biology, Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Amsterdam. |
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| Abstract: | In mouse embryos, the int-1 proto-oncogene is transiently expressed in areas of the developing neural system. Retinoic acid-treated P19 embryonal carcinoma cells have often been used as an in vitro model for the molecular basis of neural development. We shown here that int-1 is transiently expressed in differentiated P19 cells. The time course and retinoic acid dose dependence of int-1 expression suggest that the gene is specifically expressed during early neural differentiation. P19 cells may be a useful model to assist in the study, at the cellular level, of the role of int-1 in neural development. |
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