Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus. |
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| Authors: | T M Kündig I Castelmur M F Bachmann D Abraham D Binder H Hengartner and R M Zinkernagel |
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| Affiliation: | T M Kündig, I Castelmur, M F Bachmann, D Abraham, D Binder, H Hengartner, and R M Zinkernagel |
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| Abstract: | Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes. |
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