Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p |
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| Authors: | Arinami Tadao Ohtsuki Tsuyuka Ishiguro Hiroki Ujike Hiroshi Tanaka Yuji Morita Yukitaka Mineta Mari Takeichi Masashi Yamada Shigeto Imamura Akira Ohara Koichi Shibuya Haruo Ohara Kenshiro Suzuki Yasuo Muratake Tatsuyuki Kaneko Naoshi Someya Toshiyuki Inada Toshiya Yoshikawa Takeo Toyota Tomoko Yamada Kazuo Kojima Takuya Takahashi Sakae Osamu Ohmori Shinkai Takahiro Nakamura Michiko Fukuzako Hiroshi Hashiguchi Tomo Niwa Shin-ich Ueno Takuya Tachikawa Hirokazu Hori Takafumi Asada Takashi Nanko Shinichiro Kunugi Hiroshi Hashimoto Ryota Ozaki Norio Iwata Nakao Harano Mutsuo Arai Heii Ohnuma Tohru |
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| Affiliation: | The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG),Tsuyuka Ohtsuki,Hiroshi Ujike,Masashi Takeichi,Akira Imamura,Haruo Shibuya,Naoshi Kaneko,Toshiya Inada,Tomoko Toyota,Takuya Kojima,Ohmori Osamu,Michiko Nakamura,Tomo Hashiguchi,Takuya Ueno,Takafumi Hori,Shinichiro Nanko,Ryota Hashimoto,Nakao Iwata,Heii Arai,Ichiro Kusumi,Yasuyuki Fukumaki,Hisashi Higuchi,Masanari Itokawa,Yuji Okazaki |
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| Abstract: | The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a multisite collaborative study group that was organized to create a national resource for affected sib pair (ASP) studies of schizophrenia in Japan. We used a high-density single-nucleotide–polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia. All subjects were Japanese. Among these families, 122 families comprised the same subjects analyzed with short tandem repeat markers. All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia. After excluding SNPs with high linkage disequilibrium, we found significant evidence of linkage of schizophrenia to chromosome 1p21.2-1p13.2 (LOD=3.39) and suggestive evidence of linkage to 14q11.2 (LOD=2.87), 14q11.2-q13.2 (LOD=2.33), and 20p12.1-p11.2 (LOD=2.33). Although linkage to these regions has received little attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis. Results of the present study—which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent—indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects. |
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