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Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion
Authors:Kristen M Stearns‐Reider  Antonio D'Amore  Kevin Beezhold  Benjamin Rothrauff  Loredana Cavalli  William R Wagner  David A Vorp  Alkiviadis Tsamis  Sunita Shinde  Changqing Zhang  Aaron Barchowsky  Thomas A Rando  Rocky S Tuan  Fabrisia Ambrosio
Affiliation:1. Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA;2. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA;3. Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA;4. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA;5. Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA;6. Center for Vascular Remodeling and Regeneration, Center for Bioengineering (CNBIO), University of Pittsburgh, Pittsburgh, PA, USA;7. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA;8. Department of Engineering, University of Leicester, Leicester, LE1 7RH, UK;9. Glenn Center for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA;10. RR&D Center, VA Palo Alto Health Care System, Palo Alto, CA, USA
Abstract:
Keywords:aging  extracellular matrix  satellite cells  muscle stem cells  skeletal muscle
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