Acylation of carcinogenic hydroxamic acids by carbamoyl phosphate to form reactive esters |
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| Authors: | Prabhakar D Lotlikar and Leida Luha |
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| Affiliation: | Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Vic. 3052, Australia |
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| Abstract: | Two methylated derivatives of arginine were isolated from the encephalitogenic protein of myelin from the central nervous system. Evidence is presented for the proposed structures, omega-NN'-dimethylarginine and omega-N-monomethylarginine. In the encephalitogenic protein from human brain the proportion 1:6:10 for arginine:monomethylarginine:dimethylarginine residues was found to occur at position 107. Possible roles for the methylated arginine in conformational changes and altered ion-exchange behaviour are discussed. |
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