Alterations in cholesterol and fatty acid biosynthesis in rat liver homogenates by aryloxy acids (Short Communication) |
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| Authors: | Robert J Olson Thomas E Trumble and Wilbert Gamble |
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| Affiliation: | Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Ore. 97331, U.S.A. |
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| Abstract: | 2,4-Dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid inhibited the incorporation of 2-(14)C]mevalonate into cholesterol and non-saponifiable lipids. Both compounds inhibited the conversion of 1-(14)C]isopentenyl pyrophosphate into cholesterol and the synthesis of cholesterol and fatty acids from 2-(14)C]acetate. There was no inhibition of the conversion of 1-(14)C]mevalonate into CO(2). At low concentrations (0.5mm) of the compounds there was a stimulation of acetate incorporation into fatty acids. |
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