Identification of the L,D-transpeptidases responsible for attachment of the Braun lipoprotein to Escherichia coli peptidoglycan |
| |
| Authors: | Magnet Sophie Bellais Samuel Dubost Lionel Fourgeaud Martine Mainardi Jean-Luc Petit-Frère Sébastien Marie Arul Mengin-Lecreulx Dominique Arthur Michel Gutmann Laurent |
| |
| Affiliation: | INSERM, U655-LRMA, Université Pierre et Marie Curie, Centre de Recherches Biomédicales des Cordeliers, Paris, France. sophie.magnet@bhdc.jussieu.fr |
| |
| Abstract: | The L,D-transpeptidase Ldt(fm) catalyzes peptidoglycan cross-linking in beta-lactam-resistant mutant strains of Enterococcus faecium. Here, we show that in Escherichia coli Ldt(fm) homologues are responsible for the attachment of the Braun lipoprotein to murein, indicating that evolutionarily related domains have been tailored to use muropeptides or proteins as acyl acceptors in the L,D-transpeptidation reaction. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
