Protective efficacy of an AIDS vaccine,a single DNA priming followed by a single booster with a recombinant replication-defective Sendai virus vector,in a macaque AIDS model |
| |
| Authors: | Takeda Akiko Igarashi Hiroko Nakamura Hiromi Kano Munehide Iida Akihiro Hirata Takahiro Hasegawa Mamoru Nagai Yoshiyuki Matano Tetsuro |
| |
| Affiliation: | Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. |
| |
| Abstract: | We previously demonstrated the excellent protective efficacy of DNA priming followed by Gag-expressing Sendai virus (SeV) boosting (DNA prime/SeV-Gag boost vaccine) against a pathogenic simian-human immunodeficiency virus (SHIV89.6PD) infection in macaques. Here we show that we established a practical, safer AIDS vaccine protocol, a single DNA priming followed by a single booster with a recently developed replication-defective F deletion SeV-expressing Gag, and show its protective efficacy against SHIV89.6PD infections. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
