Membrane remodeling from N-BAR domain interactions: insights from multi-scale simulation |
| |
| Authors: | Ayton Gary S Blood Philip D Voth Gregory A |
| |
| Affiliation: | Center for Biophysical Modeling and Simulation, University of Utah, Salt Lake City, Utah, USA. |
| |
| Abstract: | Liposome remodeling processes (e.g., vesiculation and tubulation) due to N-BAR domain interactions with the lipid bilayer are explored with a multi-scale simulation approach. Results from atomistic-level molecular dynamics simulations of membrane binding to the concave face of N-BAR domains are used along with discretized mesoscopic field-theoretic simulations to examine how the spontaneous curvature fields generated by N-BAR domains result in membrane remodeling. It is found that tubulation can be generated by anisotropic N-BAR spontaneous curvature fields, whereas vesiculation is only observed with isotropic N-BAR spontaneous curvature fields at high density. The results of the multi-scale simulations provide insight into recent experimental observations. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
