Nonhepatic cell lines HeLa and 293 support efficient replication of the hepatitis C virus genotype 2a subgenomic replicon |
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| Authors: | Kato Takanobu Date Tomoko Miyamoto Michiko Zhao Zijiang Mizokami Masashi Wakita Takaji |
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| Affiliation: | Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan. |
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| Abstract: | ![]()
The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis revealed that mutations in HCV-derived regions were not essential for replication in these cells, as some clones displayed no mutations. |
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