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Lactuca capensis reverses memory deficits in Aβ1‐42‐induced an animal model of Alzheimer's disease |
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| Authors: | Paula Alexandra Postu Jaures A K Noumedem Oana Cioanca Monica Hancianu Marius Mihasan Mitica Ciorpac Dragos Lucian Gorgan Brindusa Alina Petre Lucian Hritcu |
| Affiliation: | 1. Department of Biology, Alexandru Ioan Cuza University of Iasi, Iasi, Romania;2. P?le Recherche Innovation et Entrepreneuriat (PRIE), Institut Universitaire de la C?te, Douala, Cameroon;3. Faculty of Pharmacy, University of Medicine and Pharmacy ‘Gr. T. Popa’, Iasi, Romania;4. Department of Chemistry, Alexandru Ioan Cuza University of Iasi, Iasi, Romania |
| Abstract: | We investigated the neuropharmacological effects of the methanolic extract from Lactuca capensis Thunb. leaves (100 and 200 mg/kg) for 21 days on memory impairment in an Alzheimer's disease (AD) rat model produced by direct intraventricular delivery of amyloid‐β1‐42 (Aβ1‐42). Behavioural assays such as Y‐maze and radial arm maze test were used for assessing memory performance. Aβ1‐42 decreased cognitive performance in the behavioural tests which were ameliorated by pre‐treatment with the methanolic extract. Acetylcholinesterase activity and oxidant–antioxidant balance in the rat hippocampus were abnormally altered by Aβ1‐42 treatment while these deficits were recovered by pre‐treatment with the methanolic extract. In addition, rats were given Aβ1‐42 exhibited in the hippocampus decreased brain‐derived neurotrophic factor (BDNF) mRNA copy number and increased IL‐1β mRNA copy number which was reversed by the methanolic extract administration. These findings suggest that the methanolic extract could be a potent neuropharmacological agent against dementia via modulating cholinergic activity, increasing of BDNF levels and promoting antioxidant action in the rat hippocampus. |
| Keywords: | Lactuca capensis extract amyloid antioxidant brain‐derived neurotrophic factor IL‐1β dementia |
