HMQ‐T‐F2 exert antitumour effects by upregulation of Axin in human cervical HeLa cells |
| |
| Authors: | Bingling Dai Tianfeng Yang Yujiao Ma Nan Ma Xianpeng Shi Dongdong Zhang Jie Zhang Yanmin Zhang |
| |
| Affiliation: | School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, China |
| |
| Abstract: | Looking for novel, effective and less toxic therapies for cervical cancer is of significant importance. In this study, we reported that HMQ‐T‐F2(F2) significantly inhibited cell proliferation and transplantable tumour growth. Mechanistically, HMQ‐T‐F2 inhibited HeLa cell growth through repressing the expression and nuclear translocation of β‐catenin, enhancing Axin expression, as well as downregulating the Wnt downstream targeted proteins. Knock‐down of a checkpoint β‐catenin by siRNA significantly attenuated HeLa cell proliferation. Furthermore, XAV939, an inhibitor of β‐catenin, was used to treat HeLa cells and the results demonstrated that HMQ‐T‐F2 inhibited proliferation and migration via the inhibition of the Wnt/β‐catenin pathway. |
| |
| Keywords: | cervical HeLa cells HMQ‐T‐F2 proliferation Wnt/β ‐catenin signal |
|
|
