Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src. |
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| Authors: | T O Chan A Tanaka J D Bjorge and D J Fujita |
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| Affiliation: | Department of Medical Biochemistry, University of Calgary Medical Sciences Centre, Alberta, Canada. |
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| Abstract: | Chicken embryo fibroblast cells overexpressing activated mutant forms of human pp60c-src, but not those overexpressing normal human pp60c-src, exhibited high levels of type I phosphatidylinositol (PI) kinase activity associated with pp60c-src. Levels of PI kinase activity were positively correlated with src tyrosine protein kinase activity and not with absolute levels of pp60c-src. Our results suggest that a linkage exists between certain forms of pp60c-src and the PI signal transduction pathway. |
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