HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein |
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| Authors: | Brandenburg A H de Waal L Timmerman H H Hoogerhout P de Swart R L Osterhaus A D |
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| Affiliation: | Institute of Virology, Erasmus University Hospital, 3000 DR Rotterdam, The Netherlands. |
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| Abstract: | Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clearance of respiratory syncytial virus (RSV) infection. We have generated cytotoxic T-cell clones (TCC) from two infants who had just recovered from severe RSV infection. These TCC were functionally characterized and used to identify HLA class I (B57 and C12)-restricted CTL epitopes of RSV. |
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