Direct Asymmetric anti‐Mannich‐Type Reactions Catalyzed by Cinchona Alkaloid Derivatives |
| |
| Authors: | Ying Jin Di Chen Xiu Rong Zhang |
| |
| Affiliation: | 1. Department of Pharmacy, Jilin Medical College, Jilin, China;2. Department of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang, China |
| |
| Abstract: | ![]()
A series of cinchona alkaloid derivatives were used to catalyze the asymmetric anti‐Mannich‐type reaction of 3‐methyl‐2‐oxindole with N‐tosyl aryl aldimines. The resulting anti‐3,3‐disubstituted 2‐oxindole products were obtained in good yields (up to 92%) with high diastereo‐ and enantioselectivities (anti/syn up to 97:3 and 91% ee). Chirality 26:801–805, 2014. © 2014 Wiley Periodicals, Inc. |
| |
| Keywords: | cinchona alkaloid derivatives asymmetric anti‐Mannich reaction anti‐3,3‐disubstituted 2‐oxindole |
|
|
