Type I interferon is required for T helper (Th) 2 induction by dendritic cells |
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| Authors: | Jessica G Borger Sheila L Brown Lisa M Connor Adam NR Cartwright Annette M Dougall Ruud HP Wilbers Peter C Cook Lucy H Jackson‐Jones Alexander T Phythian‐Adams Cecilia Johansson Daniel M Davis Benjamin G Dewals Franca Ronchese Andrew S MacDonald |
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| Affiliation: | 1. Institute of Immunology and Infection Research, Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK;2. Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, UK;3. Malaghan Institute of Medical Research, Wellington, New Zealand;4. Fundamental and Applied Research in Animals and Health, Immunology‐Vaccinology, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium;5. Plant Sciences Department, Laboratory of Nematology, Wageningen University and Research Centre, Wageningen, The Netherlands;6. Respiratory Infection Section, National Heart and Lung Institute, Imperial College London, London, UK |
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| Abstract: | Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells (DCs) are currently unclear. We have identified a previously unrecognized role for type I IFN (IFN‐I) in enabling this process. An IFN‐I signature was evident in DCs responding to the helminth Schistosoma mansoni or the allergen house dust mite (HDM). Further, IFN‐I signaling was required for optimal DC phenotypic activation in response to helminth antigen (Ag), and efficient migration to, and localization with, T cells in the draining lymph node (dLN). Importantly, DCs generated from Ifnar1?/? mice were incapable of initiating Th2 responses in vivo. These data demonstrate for the first time that the influence of IFN‐I is not limited to antiviral or bacterial settings but also has a central role to play in DC initiation of Th2 responses. |
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| Keywords: | dendritic cell interferon priming Th2 |
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