Allan-Herndon syndrome. II. Linkage to DNA markers in Xq21. |
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| Authors: | C E Schwartz J Ulmer A Brown I Pancoast H O Goodman and R E Stevenson |
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| Affiliation: | Greenwood Genetic Center, SC 29646. |
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| Abstract: | The original family with the Allan-Herndon type of X-linked mental retardation has been investigated for linkage by using DNA probes spanning the length of the X chromosome. Available for study, over 3 generations, were 13 affected males, three obligate carriers, and three normal sons of the obligate carriers. Initial disease-to-marker analysis suggested linkage to three markers (DXYS2 7b], DXS250 GMGX22], and DXS3 p19-2]) located in Xq21. All three exhibited the same maximum lod score of 2.3 at a maximum theta of .05. Multipoint analysis using LINKMAP and a set of four DNA markers (DXYS1-DXYS2-DXS3-DXS94) gave a multipoint lod score of 3.58 for a location of the Allan-Herndon syndrome near locus DXYS1 (pDP34). Therefore, our data indicate that the gene for the Allan-Herndon syndrome is likely located in Xq21. |
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