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重度OSAS患者前额叶皮质及岛叶1H-MR波谱研究
引用本文:杨兰英,朱峰岭,章其林,吴艳梅,汪健文.重度OSAS患者前额叶皮质及岛叶1H-MR波谱研究[J].现代生物医学进展,2011,11(22):4346-4349,4353.
作者姓名:杨兰英  朱峰岭  章其林  吴艳梅  汪健文
作者单位:芜湖市第二人民医院医学影像科 安徽芜湖241000
摘    要:目的:利用氢质子MRS(1H-MRS)探讨重度阻塞性呼吸睡眠暂停综合症(Severe obstructive sleep apnea syndrome,S-OSAS)患者前额叶皮质及岛叶脑代谢产物特征。方法:选择18例S-OSAS患者(S-OSAS组)和15名健康志愿者(HC组)行左侧前额叶皮质及岛叶1H-MRS检查,测量两组左侧前额叶皮质区及岛叶N-乙酰天冬氨酸/肌酸(NAA/Cr)、胆碱/肌酸(Cho/Cr)值。对患S-OSAS累计时间与前额叶皮质及岛叶NAA/Cr作直线相关分析。结果:与正常对照组相比,S-OSAS患者左侧前额叶皮质、岛叶NAA/Cr比值降低,分别为1.43±0.47、1.34±0.06,对照组分别为1.51±0.65、1.45±0.07;S-OSAS组患者左侧前额叶皮质、岛叶Cho/Cr分别为0.90±0.08、1.19±0.13,对照组分别为0.87±0.07、1.09±0.02,两组差异有统计学意义。前额叶皮质及岛叶代谢物NAA/Cr与患S-OSAS累计时间成负相关性(r值分别为-0.965、-0.955,P<0.01)。结论:1H-MRS显示S-OSAS患者前额叶皮质及岛叶病理生理变化,从该区代谢物的改变反应出S-OSAS患者执行及情感功能的异常,其NAA/Cr改变程度与患S-OSAS累计时间相关。

关 键 词:阻塞性呼吸睡眠暂停综合症  磁共振波谱  额叶前皮质  岛叶

A Study of 1H-MR Spectroscopy in the Prefrontal Cortex and Insula of Patients with Severe OSAS
YANG Lan-ying,ZHU Feng-ling,ZHANG Qi-lin,WU Yan-mei,WANG Jian-wen.A Study of 1H-MR Spectroscopy in the Prefrontal Cortex and Insula of Patients with Severe OSAS[J].Progress in Modern Biomedicine,2011,11(22):4346-4349,4353.
Authors:YANG Lan-ying  ZHU Feng-ling  ZHANG Qi-lin  WU Yan-mei  WANG Jian-wen
Affiliation:YANG Lan-ying,ZHU Feng-ling,ZHANG Qi-lin,WU Yan-mei,WANG Jian-wen(Department of Radiology,the second Hospital of Wuhu,Wuhu 241000,China)
Abstract:Objective: To explore the characteristics of proton magnetic resonance spectroscopy(1H-MRS) in the prefrontal cortex and insula of patiens with severe obstructive sleep apnea syndrome(S-OSAS).Methods: 18 patients with S-OSAS and 15 healthy controls(HC)were studied using 1H-MRS to detect the changes of left prefrontal cortex and insula.he ratio of N-acetylaspartate/creatine(NAA/Cr) and choline/creatine(Cho/Cr) was respectively measured in the left prefrontal cortex and insula.Results: As compared with health...
Keywords:Obstructive sleep apnea syndrome  Magnetic resonance spectroscopy  Prefrontal cortex  Insula  
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