Alpha-glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum |
| |
| Authors: | Courageot M P Frenkiel M P Dos Santos C D Deubel V Desprès P |
| |
| Affiliation: | Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris, France. |
| |
| Abstract: | We report that endoplasmic reticulum alpha-glucosidase inhibitors have antiviral effects on dengue (DEN) virus. We found that glucosidase inhibition strongly affects productive folding pathways of the envelope glycoproteins prM (the intracellular glycosylated precursor of M membrane protein]) and E (envelope protein): the proper folding of prM bearing unprocessed N-linked oligosaccharide is inefficient, and this causes delayed formation of prME heterodimer. The complexes formed between incompletely folded prM and E appear to be unstable, leading to a nonproductive pathway. Inhibition of alpha-glucosidase-mediated N-linked oligosaccharide trimming may thus prevent the assembly of DEN virus by affecting the early stages of envelope glycoprotein processing. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
