Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli |
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| Authors: | Denamur Erick Tenaillon Olivier Deschamps Catherine Skurnik David Ronco Esthel Gaillard Jean Louis Picard Bertrand Branger Catherine Matic Ivan |
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| Affiliation: | INSERM U571 and Université Paris 5, France. |
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| Abstract: | In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequencies have significantly more antibiotic resistances than strains having low and high mutation frequencies. |
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