Piezoelectric poly(vinylidene fluoride) microstructure and poling state in active tissue engineering |
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| Authors: | Clarisse Ribeiro Daniela M Correia Sylvie Ribeiro Vítor Sencadas Gabriela Botelho Senentxu Lanceros‐Méndez |
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| Affiliation: | 1. Centro/Departamento de Física, Universidade do Minho, Braga, Portugal;2. INL—International Iberian Nanotechnology Laboratory, Braga, Portugal;3. Centro/Departamento de Química, Universidade do Minho, Braga, Portugal;4. Escola Superior de Tecnologia, Instituto, Politécnico do Cávado e do Ave, Barcelos, Portugal |
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| Abstract: | Tissue engineering strategies rely on suitable membranes and scaffolds, providing the necessary physicochemical stimuli to specific cells. This review summarizes the main results on piezoelectric polymers, in particular poly(vinylidene fluoride), for muscle and bone cell culture. Further, the relevance of polymer microstructure and surface charge on cell response is demonstrated. Together with the necessary biochemical cues, the proper design of piezoelectric polymers can open the way to novel and more reliable tissue engineering strategies for cells in which electromechanical stimuli are present in their environment. |
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| Keywords: | Cell behavior Physical stimuli Piezoelectric polymer Poly(vinylidene fluoride) Surface topography |
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