Bioactive Tyrosine‐Derived Cytochalasins from Fungus Eutypella sp. D‐1 |
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| Authors: | Jing‐Tang Liu Bo Hu Yun Gao Jian‐Peng Zhang Bing‐Hua Jiao Xiao‐Ling Lu Xiao‐Yu Liu |
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| Affiliation: | 1. College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, P.?R.China, (phone: +86‐21‐81870970‐8004 (X.‐L. L.), +86‐21‐81870972 (X.‐Y. L.);2. fax: +86‐21‐65334344) |
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| Abstract: | Three new cytochalasins Z24, Z25, Z26 ( 1 – 3 , resp.) and one known compound, scoparasin B ( 4 ), were isolated from the fungus Eutypella sp. D‐1 isolated from the soil of high latitude of the Arctic. The structures of 1 – 3 were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity toward human breast cancer MCF‐7 cell line with IC50 of 9.33 μM . |
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| Keywords: | Eutypella Cytochalasins Arctic fungi Fungi Cytotoxic activity |
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