Sesquiterpenoids from Chloranthus henryi and Their Anti‐neuroinflammatory Activities |
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| Authors: | Li‐Jun Wang Juan Xiong Shu‐Ting Liu Xin‐Hua Liu Jin‐Feng Hu |
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| Affiliation: | 1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Road, Shanghai 201203, P.?R. China, (phone/fax: +86?21?51980172);2. Department of Pharmacology, School of Pharmacy, Fudan University, No.?826 Zhangheng Road, Shanghai 201203, P.?R. China |
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| Abstract: | Five new and seven known mono‐sesquiterpenoids ( 1 – 5 and 6 – 12 , resp.) together with five known lindenane‐type disesquiterpenoids, 13 – 17 , were isolated from the whole plant of Chloranthus henryi. Based on spectroscopic methods, the new structures were established to be (5S,6R,8S,10R)‐6‐hydroxyeudesma‐4(15),7(11)‐diene‐12,8‐olide ( 1 ), 6α‐hydroxyeudesma‐4(15),7(11),8(9)‐triene‐12,8‐olide ( 2 ), 8,12‐epoxy‐1β‐hydroxyeudesma‐4(15),7,11‐trien‐6‐one ( 3 ), 12‐oxochloraniolide A ( 4 ), and (4α)‐8‐hydroxy‐12‐norcardina‐6,8,10‐trien‐11‐one ( 5 ), respectively. Among the isolates, compound 2 , zederone epoxide ( 8 ), spicachlorantin G ( 13 ), chloramultilide A ( 14 ), shizukaol B ( 15 ), and spicachlorantin B ( 17 ) showed significant anti‐neuroinflammatory effects by inhibiting nitric‐oxide (NO) production in lipopolysaccharide (LPS)‐stimulated murine BV‐2 microglial cells with relatively low cytotoxicity. |
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| Keywords: | Chloranthus henryi Sesquiterpenes Lindenane dimers Anti‐neuroinflammation |
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