Chemical and Biological Evaluation of Hypericum maculatum Crantz Essential Oil |
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| Authors: | Aleksandra S Ðor?evi? Jelena S Lazarevi? Goran M Petrovi? Bojan K Zlatkovi? Slavica R Soluji? |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science and Mathematics, University of Ni?, Vi?egradska 33, RS‐18000 Ni? (phone: +381‐18‐533015;2. fax: +381‐18‐533014);3. Department of Pharmacy, Faculty of Medicine, University of Ni?, Bulevar Dr Zorana Din?i?a 81, RS‐18000 Ni?;4. Department of Biology and Ecology, Faculty of Science and Mathematics, University of Ni?, Vi?egradska 33, RS‐18000 Ni?;5. Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovi?a 12, RS‐34000 Kragujevac |
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| Abstract: | The chemical composition and the antimicrobial activity of the essential oil isolated from the aerial parts of Hypericum maculatum Crantz were determined. In total, 109 compounds were identified, with germacrene D (21.5%), nonane (6.5%), (E)‐β‐farnesene (5.3%), δ‐cadinene (4.5%), and ledol (4.4%) as the main constituents. The chemical compositions of this oil and of four previously studied H. maculatum oils were compared using multivariate statistical analyses, viz., agglomerative hierarchical cluster and principal component analyses. Based on the results, the interrelationship among the hitherto studied H. maculatum oil samples, including the oil characterized here, was discussed. The study of the antimicrobial potential of the oil against five bacterial and two fungal strains showed that the oil had mainly moderate antimicrobial effects. |
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| Keywords: | Hypericum maculatum Essential oils Antimicrobial activity Agglomerative hierarchical clustering (AHC) Principal component analysis (PCA) |
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