Preference for guanosine at first codon position in highly expressed Escherichia coli genes. A relationship with translational efficiency. |
| |
| Authors: | G Gutirrez L Mrquez and A Marín |
| |
| Affiliation: | G Gutiérrez, L Márquez, and A Marín |
| |
| Abstract: | The variation in base composition at the three codon sites in relation to gene expressivity, the latter estimated by the Codon Adaptation Index, has been studied in a sample of 1371 Escherichia coli genes. Correlation and regression analyses show that increasing expression levels are accompanied by higher frequencies of base G at first, of base A at second and of base C at third codon positions. However, correlation between expressivity and base compositional biases at each codon site was only significant and positive at first codon position. The preference for G-starting codons as gene expression level increases is discussed in terms of translational optimization. |
| |
| Keywords: | |
|
|
