Antifungal Monoterpene Derivatives from the Plant Endophytic Fungus Pestalotiopsis foedan |
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| Authors: | Dan Xu Bing‐Yang Zhang Xiao‐Long Yang |
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| Affiliation: | 1. Innovative Drug Research Centre, Chongqing University (Huxi Campus), Chongqing, P. R. China;2. College of Pharmaceutical Science, Hebei University, Baoding, P. R. China |
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| Abstract: | A new monoterpene lactone, (1R,4R,5R,8S)‐8‐hydroxy‐4,8‐dimethyl‐2‐oxabicyclo3.3.1]nonan‐3‐one ( 1 ), along with one related known compound, (2R)‐2‐(1R)‐4‐methylcyclohex‐3‐en‐1‐yl]propanoic acid ( 2 ), were isolated from the liquid culture of the plant endophytic fungus Pestalotiopsis foedan obtained from the branch of Bruguiera sexangula. The structure and absolute configuration of 1 were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the optical rotation (OR) and 13C‐NMR. Both compounds exhibited strong antifungal activities against Botrytis cinerea and Phytophthora nicotianae with MIC values of 3.1 and 6.3 μg/ml, respectively, which are comparable to those of the known antifungal drug ketoconazole. Compound 2 also showed modest antifungal activity against Candida albicans with a MIC value of 50 μg/ml. |
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| Keywords: | Endophytic fungi
Bruguiera sexangula
Pestalotiopsis foedan
Monoterpene Antifungal activities |
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