Characterization of the DNA gyrase from the thermoacidophilic archaeon Thermoplasma acidophilum |
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| Authors: | Yamashiro Kan Yamagishi Akihiko |
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| Affiliation: | Department of Molecular Biology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. |
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| Abstract: | ![]()
Thermoplasma acidophilum is sensitive to the antibiotic drug novobiocin, which inhibits DNA gyrase. We characterized DNA gyrases from T. acidophilum strains in vitro. The DNA gyrase from a novobiocin-resistant strain and an engineered mutant were less sensitive to novobiocin. The novobiocin-resistant gyrase genes might serve as T. acidophilum genetic markers. |
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