Human herpesvirus 6 variant A glycoprotein H-glycoprotein L-glycoprotein Q complex associates with human CD46 |
| |
| Authors: | Mori Yasuko Yang Xuwei Akkapaiboon Pilailuk Okuno Toshiomi Yamanishi Koichi |
| |
| Affiliation: | Department of Microbiology, Osaka University Medical School, Suita, Osaka 565-0871, USA. ymori@micro.med.osaka-u.ac.jp |
| |
| Abstract: | Human CD46 is a cellular receptor for human herpesvirus 6 (HHV-6). Virus entry into host cells requires a glycoprotein H (gH)-glycoprotein L (gL) complex. We show that the CD46 ectodomain blocked HHV-6 infection and bound a complex of gH-gL and the 80-kDa U100 gene product, designated glycoprotein Q, indicating that the complex is a viral ligand for CD46. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
