Development of a dual recombinant vaccine to protect small ruminants against peste-des-petits-ruminants virus and capripoxvirus infections |
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| Authors: | Berhe G Minet C Le Goff C Barrett T Ngangnou A Grillet C Libeau G Fleming M Black D N Diallo A |
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| Affiliation: | Cirad, Programme Santé Animale, Campus International de Baillarguet, 34398 Montpellier Cedex 05, France. |
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| Abstract: | A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against challenge with a virulent PPRV strain. |
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