Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. |
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| Authors: | J G Giri M Ahdieh J Eisenman K Shanebeck K Grabstein S Kumaki A Namen L S Park D Cosman and D Anderson |
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| Affiliation: | Immunex Research and Development Corporation, Seattle, WA 98101. |
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| Abstract: | We have recently cloned a novel cytokine, IL-15, with shared bioactivities but no sequence homology with IL-2. We found high affinity IL-15 binding to many cell types, including cells of non-lymphoid origin. Analysis of IL-15 interaction with subunits of the IL-2 receptor (IL-2R) revealed that the alpha subunit was not involved in IL-15 binding. We demonstrated directly in cells transfected with IL-2R subunits that both the beta and gamma chains are required for IL-15 binding and signaling. Hence, IL-15, like IL-2, IL-4 and IL-7, utilizes the common IL-2R gamma subunit found to be defective in X-linked severe combined immunodeficiency in humans. IL-15 is the only cytokine other than IL-2 that has also been shown to share the beta signaling subunit of IL-2R. The differential ability of some cells to bind and respond to IL-2 and IL-15 implies the existence of an additional IL-15-specific component. |
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